Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes
نویسندگان
چکیده
منابع مشابه
Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes
In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are far more abundant in complementarity-determining regions (CDRs) of IgV-region genes than expected for random codon use or from s...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2016
ISSN: 1664-3224
DOI: 10.3389/fimmu.2016.00525